| 英文名称 | Anti-Bax Polyclonal Antibody |
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| 宿主 | Rabbit |
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| 别名 | BCL2L4;Bax-protein;BAX_HUMAN;BAXA
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| 应用 | WB IHC IF |
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| 稀释比例 | WB 1:500-2000. IHC 1:50-100. IF 1:50-200. |
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| 蛋白分子量 | 21kDa |
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| Gene ID | 581 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
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| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Recombinant Protein of human Bax |
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| 性状 | 液体 |
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| Public Immunogen Range | Recombinant Protein of human Bax |
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| Subcellular Locations | Cytoplasm Cytoplasm Mitochondrion membrane Single-pass membrane protein |
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| Swiss Prot | Q07812 |
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| *类型 | Polyclonal Antibody |
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| 背景资料 | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
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