产品简介    

  1. 中文名：     苯甲基黄酰氟    

  2. 英文名：     α-Toluenesulfonyl fluoride ；   Benzylsulfonyl fluoride   ；   PMSF      

  3. 别  名：     苯*    

  4.CAS 号：     329-98-6    

  5. 分子式：     C7H7SO2F     

  6. 分子量：     174.2     

  7. 熔  点：     91-95℃    

  8.   溶解性：难溶于水，且在水溶液中非常不稳定。可溶于异丙 醇、乙醇和甲醇    

  9.   外        观：白色针状结晶    

 10. 货  号：   P8320      

 12.   储存条件：室温    

 13. 作  用：     是一种蛋白酶抑制剂，用异丙醇溶解后分装成小包装-20℃保存。有效浓度为0.1-1mM。   苯甲基黄酰氟   可抑制丝氨酸蛋白酶例如胰蛋白酶(trypsin)和胰凝乳蛋白酶(chymotrypsin)，也可抑制半胱氨酸蛋白酶和乙酰胆碱酯酶。有效浓度为0.1-1mM。    

参考文献：

《Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation》 作者:XIN-BIN GUO,XIN DENG,YING WEI 期刊:Wiley Online Library 影响因子: PMID:29139175

《Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism》 作者:Yawen Ji，Panpan Zhang，Yixiao Xing，Linglu Jia，Yunpeng Zhang，Tingting Jia，Xuan Wu，Bin Zhao，Xin Xu 期刊:International Journal of Molecular Medicine 影响因子:2.928 PMID:30365053

《Protective effect of silkworm pupa oil on hydrochloric acid/ethanol‐induced gastric ulcers》 作者:Xingyao Long, Xin Zhao, Wei Wang, Yu Zhang, Hongwei Wang, Xinqi Liu, Huayi Suo 期刊:Journal of the Science of Food and Agriculture 影响因子:2.422 PMID:30479041

《Regulation of insulin resistance by targeting the insulin‐like growth factor 1 receptor with microRNA‐122‐5p in hepatic cells》 作者:Li Dong, Xiaoyu Hou, Fengsui Liu, Hong Tao, Yunjia Zhang, Hang Zhao, Guangyao Song 期刊:Cell Biology International Homepage 影响因子:2.127 PMID:30958584

《Pro-apoptotic effect of TRAIL-transfected endothelial progenitor cells on glioma cells》 作者:Xin Deng,Wen Zhao,Laijun Song,Wei Ying,Xinbin Guo 期刊:Oncology Letters 影响因子:0.237 PMID:29545899

《Disparate expression of autophagy in corneas of C57BL/6 mice and BALB/c mice after Aspergillus fumigatus infection》 作者:Chen-Yu Li, Cui Li, Hui Li, Gui-Qiu Zhao, Jing Lin, Qian Wang, Xu-Dong Peng, Qiang Xu, Guo-Qiang Zhu, and Jia-Qian Jiang 期刊:International Journal of Ophthalmology 影响因子:1.189 PMID:31131226

《Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway》 作者:Yi He, Zeng Zisan, Zhenhui Lu, Li Zheng, Jinmin Zhao 期刊:FEBS OpenBio 影响因子:1.959 PMID:31037830

《Corrigendum: HAX-1 protects glioblastoma cells from apoptosis through the Akt1 pathway》 作者:Xin Deng, Laijun Song, Wen Zhao, Ying Wei and Xin-bin Guo 期刊:Frontiers in Cellular Neuroscience 影响因子:3.9 PMID:30766479

《Regulation of lipoxygenase-1 and Dectin-1 on interleukin-10 in mouse Aspergillus fumigatus keratitis》 作者:Cheng-Ye Che, Ke-Lan Yuan, Gui-Qiu Zhao, Cui Li, Jing Lin, Guo-Qiang Zhu, and Min Liu 期刊:International journal of Ophthalmology 影响因子:1.189 PMID:29977799

《p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer’s Disease》 作者:Ding, Yanfeia | Bao, Xiaomingb | Lao, Lifenga | Ling, Yunxianga | Wang, Qinwena | Xu, Shujuna; * 期刊:Journal of Alzheimer's Disease 影响因子:3.476 PMID:

《Regulation by Hsp27/P53 in testis development and sperm apoptosis of male cattle (cattle‐yak and yak)》 作者:Penggang Liu  Sijiu Yu  Yan Cui  Junfeng He  Qian Zhang  Juan Sun  Yufeng Huang  Xiaoqing Yang Mixia Cao  Bo Liao  Junxing Ma 期刊:Journal of cellular physiology 影响因子:3.923 PMID:30132847

《A Host Factor GPNMB Restricts Porcine Circovirus Type 2 (PCV2) Replication and Interacts With PCV2 ORF5 Protein》 作者:Kangkang Guo, Lei Xu, Mengmeng Wu, Yufeng Hou, Yanfen Jiang, Jiangman Lv, Panpan Xu, Zhixin Fan, Ruiqi Zhang, Fushan Xing and Yanming Zhang 期刊:Frontiers in Microbiology 影响因子:4.019 PMID:30671053

《Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis》 作者:Kelan Yuan,Guiqiu Zhao,Chengye Che,Cui Li,Jing Lin,Guoqiang Zhu,Kun He 期刊:International Immunopharmacology 影响因子:3.118 PMID:28926773

《Neuregulin 1 Enhances Cell Adhesion Molecule L1 Expression in Human Glioma Cells and Promotes Their Migration as a Function of Malignancy》 作者:Wei-Jiang Zhao,Melitta Schachner, 期刊:Journal of Neuropathology experimental neurlogy 影响因子:3.797 PMID:23399902

《Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism》 作者:Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan and Xingxu Zhao 期刊:Reproductive Biology and Endocrinology 影响因子:2.852 PMID:30606208

"《Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro》 作者:Chengrui Nan,Li Guo,Zongmao Zhao,Shucheng Ma,Jixiang Liu,Dongdong Yan,Guoqiang Song,Hanjie Liu 期刊:International

Journal of

Oncology 影响因子:3.333 PMID:27035275"

《Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma》 作者:Xinan Shi， Hongjian Li， Hong Yao， Xu Liu ，Ling Li， Kwong?Sak Leung， Hsiang?Fu Kung ，Marie Chia?Mi Lin 期刊:Molecular Medicine Reports 影响因子:1.922 PMID:26398439

《Expression Profiles Analysis and Functional Characterization of MicroRNA‐660 in Skeletal Muscle Differentiation》 作者:B Yue, J Wu, Y Wang, C Zhang 期刊:Journal of cellular Biochemistry 影响因子:3.062 PMID:28106300

《High Expression of IL-4R Enhances Proliferation and Invasion of Hepatocellular Carcinoma Cells》 作者:C Guo, Y Ouyang, J Cai, L Xiong 期刊:The International Journal of Biological Markers 影响因子:1.449 PMID:28665449

《Allicin inhibits human renal clear cell carcinoma progression via suppressing HIF pathway》 作者:B Song, Y Shu, T Cui, P Fu 期刊:International Journal of Clinical and Experimental Medicine 影响因子:1.422 PMID:26884975

《Simvastatin Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition in Human Alveolar Epithelial Cells》 作者:Yang T, Chen M, Sun T 期刊:Cellular Physiology and Biochemistry 影响因子:2.561 PMID:23817018

《IL-17A/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer》 作者:Zhenhua Wu,Dan He,Shuyuan Zhao,Hongjiang Wang 期刊:Molecular and cellular biochemistry 影响因子:3.062 PMID:30564960

《MicroRNA-34a induces apoptosis in the human glioma cell line, A172, through enhanced ROS production and NOX2 expression》 作者:SZ Li, YY Hu, J Zhao, YB Zhao, JD Sun, Y Yang 期刊:Biochemical and Biophysical Research Communication 影响因子:2.559 PMID:24393844

《The 308-nm excimer laser stimulates melanogenesis via the wnt/β-Catenin signaling pathway in B16 cells》 作者:Lili Li, Yanping Liang, Donghong Zhang, Chen Wang, Nannan Pan, Jiqiong Hong 期刊:Journal of Dermatological Treatment 影响因子:3.675 PMID:30661431

《miR?199b?5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1》 作者:Anhao Wu,Yan Chen,Yang Liu,Yafang Lai,Dequan Liu 期刊:Oncology Letters 影响因子:1.664 PMID:30250555

"《CD4分子在牦牛主要淋巴器官的表达》 作者:张倩 杨琨 黄玉风 余四九 潘阳阳 何俊峰 崔燕 期刊:农 业 生 物 技 术 学 报

Journal of Agricultural Biotechnology 影响因子:0.8 PMID:"

《The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection》 作者:Yifan Zhou，Jing Lin，Xudong Peng，Cui Li，Jie Zhang，Qian Wang，Guoqiang Zhu，Jia You，Guiqiu Zhao 期刊:International Immunopharmacology 影响因子:3.361 PMID:30952101

《Maresin1 regulates neutrophil recruitment and IL-10 expression in Aspergillus fumigatus keratitis》 作者:Qing Tang，Chengye，Che，Jing Lin，Hong，He，Wenyi，Zhao，Leyu Lv，Guiqiu，Zhao 期刊:International Immunopharmacology 影响因子:3.361 PMID:30690344

《MicroRNA-378-3p/5p suppresses migration and invasion of oral squamous carcinoma cells by inhibiting KLK4 expression》 作者:Zhi Cui, Shiqun Sun, Qilin Liu, Xuechun Zhou, Siyu Gao, Peixuan Peng, Qianpeng Li 期刊:Biochemistry and Cell Biology 影响因子:2.014 PMID:31265790

《Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis》 作者:Jia-Qian Jiang, Cui Li, Cong-Xian Cui, Yu-Na Ma, Gui-Qiu Zhao, Xu-Dong Peng, Qiang Xu, Qian Wang, Guo-Qiang Zhu, and Chen-Yu Li 期刊:International Journalof Ophthalmology 影响因子:1.189 PMID:31236343

《Expression of macrophage migration inhibitory factor in Aspergillus fumigatus keratitis》 作者:Qiang Xu, Li-Ting Hu, Qian Wang, Jing Lin, Nan Jiang, Cui Li, and Gui-Qiu Zhao 期刊:International Journal of Ophthalmology 影响因子:1.189 PMID:31131227

《Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin》 作者:Litong Fan,  Jiaqing Chen  ,Yanmeng Tao , Boon Chin Heng  ,Jiakuo Yu , Zheng Yang , Zigang Ge 期刊:Journal of Orthopaedic Research 影响因子:3.043 PMID:30644571

《Protecting intestinal epithelial cells against deoxynivalenol and E. coli damage by recombinant porcine IL-22》 作者:Yunyun Li，Jinquan Wang，Yuchen Li，Haiqin Wu，Shiyi Zhao，Qinghua Yua 期刊:Veterinary Microbiology 影响因子:2.791 PMID:30955803

《A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus》 作者:Li-Dan Zhang，Qiu-Cheng Cai，Ji-Hui Cui，Wei Zhang ，Shu-Mei Dong，Wei Xiao，Jiang Li，Tian-Chao Kou，Xue-Wen Zhang，Hao-Juan He，Lei Ding，Yang Yang，Jian-Hua Lai，Ming Li，Qi-Shun Zhu，Kai-Jun Luo 期刊:Developmental & Comparative Immunology 影响因子:3.119 PMID:30471301

《Herbacetin treatment remitted LPS induced inhibition of osteoblast differentiation through blocking AKT/NF-κB signaling pathway》 作者:Pengshan Cai, Teng Cai, Xiaobin Li, Lei Fan, Guang Chen, Bofan Yu, and Tao Liu 期刊:American Journal of Translational Research 影响因子:3.266 PMID:30899386

《Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis》 作者:Zhichu Xiang,Gexuan Jiang , Xiaoliang Yang ,Di Fan ,Xiaohui Nan ,Dan Li, Zhiyuan Hu and Qiaojun Fang 期刊:Biomolecules 影响因子:4.694 PMID:31060320

《Chronic toxicity and biochemical response of Apis cerana cerana (Hymenoptera: Apidae) exposed to acetamiprid and propiconazole alone or combined》 作者:Wensu Han，Yemeng Yang，Jinglin Gao，Dongxiang Zhao，Chengcai Ren，Shijie Wang，Shan ZhaoYihai Zhong 期刊:Ecotoxicology 影响因子:2.46 PMID:30874992

《Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms》 作者:Jianxia Wen，Jian Wang，Pengyan Li，Ruilin Wang，Jiabo Wang，Xuelin Zhou，Lu Zhang，Haotian Li，Shizhang Wei，Huadan Cai，Yanling Zhao 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:31028997

《Cobalt phosphide nanowires for fluorometric detection and in-situ imaging of telomerase activity via hybridization chain reactions》 作者:Li Zhang,Jie Peng,Ming-Fang Hong,Jia-Qing Chen,Ru-Ping Liang,Jian-Ding Qiu 期刊:Microchimica Acta 影响因子:5.479 PMID:31037462

《Integrin αvβ6 mediates epithelial-mesenchymal transition in human bronchial epithelial cells induced by lipopolysaccharides of Pseudomonas aeruginosa via TGF-β1-Smad2/3 signaling pathway》 作者:Weiming Liu,Tieying Sun,Yong Wang 期刊:Folia Microbiologica 影响因子:1.448 PMID:31243731

《DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4》 作者:Shichen Sun,Miao Yu,Zhuangzhuang Fan,I-Ting Yeh,Hailan Feng,Haochen Liu,Dong Han 期刊:Biochemical and Biophysical Research Communications 影响因子:2.705 PMID:31202458

《Ursolic Acid Attenuates TGF-β1-Induced Epithelial‐Mesenchymal Transition in NSCLC by Targeting Integrin αVβ5/MMPs Signaling》 作者:Ruan, Jun Shan; Zhou, Huan; Yang, Lin; Wang, Ling; Jiang, Zong Sheng; Sun, Hong; Wang, Shao Ming 期刊:Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 影响因子: PMID:28911340

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