Anti-AURKA Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108267P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-07-19
产地 北京
品牌 Solarbio
货号 K108267P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB IHC
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
纯度 %
亚型 IgG
浓度 %
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle; centrosome duplication; centrosome separation as well as maturation; chromosomal alignment; spindle assembly checkpoint; and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins; including ARHGEF2; BORA; BRCA1; CDC25B; DLGP5; HDAC6; KIF2A; LATS2; NDEL1; PARD3; PPP1R2; PLK1; RASSF1; TACC3; p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway; and particularly the checkpoint-response pathways critical for oncogenic transformation of cells; by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors; the protein phosphatase type 1 (PP1) isoforms; to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
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