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人核苷酸结合寡聚化结构域样受体蛋白 3 Elisa试剂盒
起批量( 价格
≥1 ¥2600元/盒
  • 供货能力:999
  • 最低订购量:1盒
  • 可销售总数量:999盒
  • 建议零销价:2600元/盒
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
品牌: Solarbio CAS编号:
产地: 北京 样本: 血清/血浆/细胞培养上清
标记物: 应用: Elisa试剂盒
检测方法: 双抗体夹心法 检测限: 15.6-1000 pg/ml
数量: 999 货号: SEKH-0504
纯度: % 用途范围: Human
规格: 是否进口:
保质期: 保存条件: -20
适应物种: Human
NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% and 93% aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.
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