| 英文名称 | Rabbit BCL2L1 Polyclonal Antibody |
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| 应用2 | WB IHC |
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| 克隆类型2 | Polyclonal Antibody |
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| 别名 | BCL-XL/S;BCL2L;BCLX;Bcl-X;PPP1R52
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| 应用 | WB,IHC |
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| 稀释比例 | WB1:500-1:2000 IHC1:50-1:200 |
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| 交叉反应 | Human Mouse Rat |
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| 蛋白分子量 | 26kDa |
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| Gene ID | 598 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 储存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Recombinant protein of human BCL2L1 |
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| 性状 | Lyophilized or Liquid |
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| Swiss Prot | Q07817 |
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| 克隆类型 | Polyclonal Antibody |
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| 来源 | Rabbit |
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| 背景资料 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
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