| 英文名称 | Rabbit CD40 Polyclonal Antibody |
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| 应用2 | WB IHC |
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| 克隆类型2 | Polyclonal Antibody |
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| 别名 | AC133;CD133;CORD12;MCDR2;MSTP061;PROML1;RP41;STGD4
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| 应用 | WB,IHC |
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| 稀释比例 | WB1:500-1:2000 IHC1:50-1:200 |
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| 交叉反应 | Human Mouse Rat |
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| 蛋白分子量 | 31kDa |
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| Gene ID | 958 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 储存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Recombinant Protein of human CD40 |
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| 性状 | Lyophilized or Liquid |
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| Swiss Prot | P25942 |
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| 克隆类型 | Polyclonal Antibody |
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| 来源 | Rabbit |
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| 背景资料 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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