| 英文名称 | Rabbit PSME3 Polyclonal Antibody |
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| 应用2 | WB IHC IF |
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| 克隆类型2 | Polyclonal Antibody |
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| 别名 | HEL-S-283;Ki;PA28-gamma;PA28G;PA28gamma;REG-GAMMA
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| 应用 | WB,IHC,IF |
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| 稀释比例 | WB1:500-1:2000 IHC1:50-1:200 IF1:20-1:50 |
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| 交叉反应 | Human Rat |
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| 蛋白分子量 | 30kDa |
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| Gene ID | 10197 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 储存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Recombinant protein of human PSME3 |
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| 性状 | Lyophilized or Liquid |
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| Swiss Prot | P61289 |
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| 克隆类型 | Polyclonal Antibody |
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| 来源 | Rabbit |
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| 背景资料 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.
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