| 英文名称 | Rabbit FGFR3 Polyclonal Antibody |
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| 应用2 | WB IHC |
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| 别名 | ACH;CD333;CEK2;HSFGFR3EX;JTK4
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| 应用 | WB,IHC |
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| 稀释比例 | WB1:500-1:2000 IHC1:50-1:100 |
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| 交叉反应 | Human Mouse Rat |
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| 蛋白分子量 | 88kDa |
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| Gene ID | 2261 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 储存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Recombinant protein of human FGFR3 |
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| 性状 | Lyophilized or Liquid |
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| Swiss Prot | P22607 |
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| 克隆类型 | Polyclonal Antibody |
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| 来源 | Rabbit |
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| 背景资料 | This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. |
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