Anti-CD8 Polyclonal Antibody
- 发布日期: 2019-05-13
- 更新日期: 2025-05-14
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K106402P
|
应用范围 |
WB
|
CAS编号 |
|
抗体名 |
Anti-CD8 Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
靶点 |
KCTD17
|
适应物种 |
Mouse
|
形态 |
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
CD8A;MAL;Leu2;p32;OKT8 T cell antigen
|
浓度 |
%
|
免疫原 |
A synthetic peptide of human CD8
|
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.