Anti-APP Polyclonal Antibody
- 发布日期: 2019-05-13
- 更新日期: 2025-11-06
产品详请
| 产地 |
北京
|
| 品牌 |
Solarbio
|
| 保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
| 货号 |
K106430P
|
| 应用范围 |
WB
|
| CAS编号 |
|
| 抗体名 |
Anti-APP Polyclonal Antibody
|
| 克隆性 |
Polyclonal Antibody
|
| 靶点 |
TOP2A
|
| 适应物种 |
Human Mouse Rat
|
| 形态 |
|
| 宿主 |
Rabbit
|
| 亚型 |
IgG
|
| 标识物 |
AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;preA4
|
| 浓度 |
%
|
| 免疫原 |
A synthetic peptide of human APP
|
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.