英文名称Anti-AKT1+2+3 Polyclonal Antibody

宿主Rabbit

别名AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA

应用WB稀释比例

WB 1:3000.

交叉反应Human Mouse Rat

蛋白分子量65kDaGene ID207

保存Store at -20°C. Avoid freeze / thaw cycles.

储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

纯化方法Affinity purification

亚型IgG

免疫原A synthetic peptide of human AKT1+2+3

性状液体Public Immunogen RangeA synthetic peptide of human AKT1+2+3Subcellular LocationsCell membrane Cytoplasm NucleusSwiss ProtP31749

*类型Polyclonal Antibody

背景资料The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.