| 英文名称 | Anti-BAX Polyclonal Antibody |
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| 宿主 | Rabbit |
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| 别名 | Bcl2-L-4;Bax-protein;BAX_HUMAN;BAXA |
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| 应用 | IHC |
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| 稀释比例 | IHC 1:50-200. |
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| 交叉反应 | Human |
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| 蛋白分子量 | 21kDa |
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| Gene ID | 581 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
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| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | A synthetic peptide of human BAX |
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| 性状 | 液体 |
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| Public Immunogen Range | A synthetic peptide of human BAX |
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| Swiss Prot | Q07812 |
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| Subcellular Locations | Cytoplasm Cytoplasm Mitochondrion membrane Single-pass membrane protein |
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| *类型 | Polyclonal Antibody |
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| 背景资料 | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 |
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