Anti-SMAD1 Polyclonal Antibody
- 发布日期: 2019-05-13
- 更新日期: 2025-05-06
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K107039P
|
应用范围 |
IHC
|
CAS编号 |
|
抗体名 |
Anti-SMAD1 Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
靶点 |
|
适应物种 |
Human Mouse Cow
|
形态 |
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
BSP-1;BSP1;JV4-1;JV41;MADH1;MADR1;SMAD family member 1
|
浓度 |
%
|
免疫原 |
A synthetic peptide of human SMAD1
|
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.