北京索莱宝科技有限公司
产品展厅
Anti-NR1H4 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K107059P
  • 发布日期: 2019-05-13
  • 更新日期: 2025-05-06
产品详请
产地 北京
品牌 Solarbio
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
货号 K107059P
应用范围 IHC
CAS编号
抗体名 Anti-NR1H4 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶点
适应物种 Human Mouse
形态
宿主 Rabbit
亚型 IgG
标识物 Bile acid receptor;BAR;FXR;HRR1;RIP14
浓度 %
免疫原 A synthetic peptide of human NR1H4
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, deoxycholic acid and allocholic acid. Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands.
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