Anti-NR1H4 Polyclonal Antibody
- 发布日期: 2019-05-13
- 更新日期: 2025-05-06
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K107059P
|
应用范围 |
IHC
|
CAS编号 |
|
抗体名 |
Anti-NR1H4 Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
靶点 |
|
适应物种 |
Human Mouse
|
形态 |
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
Bile acid receptor;BAR;FXR;HRR1;RIP14
|
浓度 |
%
|
免疫原 |
A synthetic peptide of human NR1H4
|
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, deoxycholic acid and allocholic acid. Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands.