Anti-STRAP Polyclonal Antibody
- 价格: ¥询价
- 发布日期: 2019-05-13
- 更新日期: 2024-05-17
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K107109P
|
应用范围 |
WB
|
抗体名 |
Anti-STRAP Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human Mouse Rat
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
MAP activator with WD repeats;MAWD;PT WD;STRAP;UNR interacting protein;UNRIP;WD 40 repeat protein PT WD
|
浓度 |
%
|
免疫原 |
Recombinant protein of human STRAP
|
Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.