Anti-MKP1 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K107192P
  • 价格: ¥询价
  • 发布日期: 2019-05-13
  • 更新日期: 2024-05-08
产品详请
产地 北京
品牌 Solarbio
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
货号 K107192P
应用范围 IHC
抗体名 Anti-MKP1 Polyclonal Antibody
克隆性 Polyclonal Antibody
适应物种 Mouse Rat
宿主 Rabbit
亚型 IgG
标识物 3ch1341;DUSP1;Ptpn10;Ptpn16
浓度 %
免疫原 A synthetic peptide of human MKP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
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