Anti-TOP2A Polyclonal Antibody
- 价格: ¥询价
- 发布日期: 2019-05-13
- 更新日期: 2024-04-30
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K107204P
|
应用范围 |
WB IHC
|
抗体名 |
Anti-TOP2A Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human Mouse Rat Pig
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
TOP2;TP2A;DNA topoisomerase 2-alpha;
|
浓度 |
%
|
免疫原 |
A synthetic peptide of human TOP2A
|
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.