Anti-NLRP3 Polyclonal Antibody
- 价格: ¥询价
- 发布日期: 2019-05-13
- 更新日期: 2024-04-30
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
货号 |
K107206P
|
应用范围 |
WB IHC
|
抗体名 |
Anti-NLRP3 Polyclonal Antibody
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human Mouse Rat
|
宿主 |
Rabbit
|
亚型 |
IgG
|
标识物 |
NLRP3;AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;FCAS;FCAS1;FCU;MWS;NALP3;PYPAF1;NLR family pyrin domain containing 3
|
浓度 |
%
|
免疫原 |
A synthetic peptide of human NLRP3
|
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.