Anti-CASP1 (p20,Cleaved-Asn120) Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K107231P
  • 价格: ¥询价
  • 发布日期: 2019-05-13
  • 更新日期: 2024-04-30
产品详请
产地 北京
品牌 Solarbio
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
货号 K107231P
应用范围 IHC
抗体名 Anti-CASP1 (p20,Cleaved-Asn120) Polyclonal Antibody
克隆性 Polyclonal Antibody
适应物种 Human
宿主 Rabbit
亚型 IgG
标识物 CASP1;ICE;IL1BC;P45;caspase-1
浓度 %
免疫原 A synthetic peptide of human CASP1 (p20,Cleaved-Asn120)
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
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