宿主 Mouse

英文名称 Anti-BCL2 Monoclonal Antibody

别名 Bcl-2;PPP1R50;Apoptosis regulator Bcl 2;B cell leukemia/lymphoma 2

应用 WB IF

稀释比例 WB 1:1000-2000. IF 1:100-200.

交叉反应 Human Mouse Rat

蛋白分子量 26kDa

Gene ID 596

保存 Store at -20°C. Avoid freeze / thaw cycles.

储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

纯化方法 Affinity purification

亚型 IgG1

免疫原 A synthetic peptide coupled to KLH

性状 液体

Public Immunogen Range A synthetic peptide coupled to KLH

Swiss Prot P10415

Subcellular Locations Endoplasmic reticulum membrane Mitochondrion outer membrane Nucleus membrane Single-pass membrane protein

*号 6B5

*类型 Monoclonal Antibody

背景资料 BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.

参考文献：

《Structural optimization and additional targets identification of antisense oligonucleotide G3139 encapsulated in a neutral cytidinyl-lipid combined with a cationic lipid in vitro and in vivo》 作者:Yuan Ma,Wenting Zhao,Yiding Li,Yufei Pan,Shuhe Wang,Yuejie Zhu,Lingxuan Kong,Zhu Guan,Jiancheng Wang,Lihe Zhang,Zhenjun Yang 期刊:Biomaterials 影响因子:10.273 PMID:30660994