K009371PAnti-Phospho-Stat3-S727 Polyclonal Antibody
  • 品牌:solarbio
  • 产地:北京
  • 货号:K009371P
  • 价格: ¥询价
  • 发布日期: 2020-03-04
  • 更新日期: 2024-06-21
产品详请
产地 北京
品牌 solarbio
货号 K009371P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 蛋白研究,分析,检测
应用范围 WB IHC IP
规格 50ul
抗体名 Anti-Phospho-Stat3-S727 Polyclonal Antibody
是否单克隆
靶点 Phospho-Stat3-S727
适应物种 Human Mouse Rat
形态 液体
宿主 Rabbit
纯度 %
亚型 IgG
浓度 %
免疫原 A synthetic phosphorylated peptide around S727 of human Stat3
是否进口
背景资料:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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