K009372PAnti-SARS spike glycoprotein S1 Polyclonal Antibody
  • 品牌:solarbio
  • 产地:北京
  • 货号:K009372P
  • 价格: ¥询价
  • 发布日期: 2020-03-04
  • 更新日期: 2024-06-21
产品详请
产地 北京
品牌 solarbio
货号 K009372P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 蛋白研究,分析,检测
应用范围 WB IHC-P IHC-F ICC IF
规格 50ul
抗体名 Anti-SARS spike glycoprotein S1 Polyclonal Antibody
是否单克隆
靶点 SARS spike glycoprotein S1
适应物种 SARS-CoV
形态 液体
宿主 Rabbit
纯度 %
亚型 IgG
浓度 %
免疫原 KLH conjugated synthetic peptide derived from SARS spike glycoprotein:101-200/1255
是否进口
背景资料:S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
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