K009372PAnti-SARS spike glycoprotein S1 Polyclonal Antibody
- 价格: ¥960/支
- 发布日期: 2020-03-04
- 更新日期: 2023-09-28
产品详请
抗体名 |
Anti-SARS spike glycoprotein S1 Polyclonal Antibody
|
是否单克隆 |
否
|
靶点 |
SARS spike glycoprotein S1
|
用途范围 |
WB 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. ICC 1:100-500. IF 1:100-500
|
形态 |
液体
|
宿主 |
Rabbit
|
纯度 |
%
|
免疫原 |
KLH conjugated synthetic peptide derived from SARS spike glycoprotein:101-200/1255
|
产地 |
北京
|
品牌 |
solarbio
|
货号 |
K009372P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
WB IHC-P IHC-F ICC IF
|
规格 |
50ul
|
产品用途 |
蛋白研究,分析,检测
|
适应物种 |
SARS-CoV
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
背景资料:S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.