背景资料：SLC43A2 (solute carrier family 43, member 2), also known as LAT4 or PP7664, is a 569 amino acid multi-pass membrane protein that belongs to the SLC43A solute transporter family. Expressed in a variety of tissues with highest expression in kidney and placenta, SLC43A2 functions as a sodium- and chloride-independent transport channel protein that facilitates the transport of large neutral amino acids across membranes. Overexpression of SLC43A2 is associated with head and neck carcinomas, implicating SLC43A2 as a tumor-associated protein.