Anti-DUSP3 Polyclonal Antibody
- 价格: ¥1600/支
- 发布日期: 2020-08-10
- 更新日期: 2023-12-06
产品详请
抗体名 |
DUSP3
|
是否单克隆 |
否
|
用途范围 |
Human
|
宿主 |
Rabbit
|
纯度 |
%
|
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K107977P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
WB
|
产品用途 |
WB
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.