Anti-TEAD2 Polyclonal Antibody
- 价格: ¥1600/支
- 发布日期: 2020-08-10
- 更新日期: 2023-12-06
产品详请
抗体名 |
TEAD2
|
是否单克隆 |
否
|
用途范围 |
Human
|
宿主 |
Rabbit
|
纯度 |
%
|
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K107981P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
IHC
|
产品用途 |
IHC
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.