Anti-TEAD2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K107981P
  • 价格: ¥1600/支
  • 发布日期: 2020-08-10
  • 更新日期: 2023-12-06
产品详请
抗体名 TEAD2
是否单克隆
用途范围 Human
宿主 Rabbit
纯度 %
产地 北京
品牌 Solarbio
货号 K107981P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 IHC
产品用途 IHC
克隆性 Polyclonal Antibody
适应物种 Human
亚型 IgG
浓度 %
是否进口
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
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