Anti-STAT3 Polyclonal Antibody
- 发布日期: 2020-08-10
- 更新日期: 2025-05-30
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K107991P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
用途 |
WB IHC
|
应用范围 |
WB IHC
|
抗原来源 |
|
CAS编号 |
|
保质期 |
|
抗体名 |
STAT3
|
是否单克隆 |
否
|
克隆性 |
Polyclonal Antibody
|
靶点 |
|
适应物种 |
Human
|
形态 |
|
宿主 |
Rabbit
|
标记物 |
|
包装规格 |
|
纯度 |
%
|
亚型 |
IgG
|
标识物 |
|
浓度 |
%
|
免疫原 |
|
是否进口 |
否
|
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.