Anti-HRAS/NRAS/KRAS Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108051P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-06-21
产品详请
产地 北京
品牌 Solarbio
货号 K108051P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 IHC
应用范围 IHC
抗体名 HRAS/NRAS/KRAS
是否单克隆
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
宿主 Rabbit
纯度 %
亚型 IgG
浓度 %
是否进口
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
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