Anti-DARC Polyclonal Antibody
- 价格: ¥1600/支
- 发布日期: 2020-08-10
- 更新日期: 2023-09-28
产品详请
抗体名 |
DARC
|
是否单克隆 |
否
|
用途范围 |
Human
|
宿主 |
Rabbit
|
纯度 |
%
|
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K108054P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
WB IHC
|
产品用途 |
WB IHC
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.