Anti-SEPTIN2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108121P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-07-19
产品详请
产地 北京
品牌 Solarbio
货号 K108121P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 WB IHC
应用范围 WB IHC
抗体名 SEPTIN2
是否单克隆
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
宿主 Rabbit
纯度 %
亚型 IgG
浓度 %
是否进口
Filament-forming cytoskeletal GTPase. Forms a 4filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
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