Anti-SPIN2B Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108149P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-05-17
抗体名 SPIN2B
用途范围 Human Mouse Rat
宿主 Rabbit
纯度 %
产地 北京
品牌 Solarbio
货号 K108149P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 IHC
产品用途 IHC
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
亚型 IgG
浓度 %
Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.
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