北京索莱宝科技有限公司
产品展厅
Anti-SPIN2B Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108149P
  • 发布日期: 2020-08-10
  • 更新日期: 2025-05-30
产品详请
产地 北京
品牌 Solarbio
货号 K108149P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 IHC
应用范围 IHC
抗原来源
CAS编号
保质期
抗体名 SPIN2B
是否单克隆
克隆性 Polyclonal Antibody
靶点
适应物种 Human Mouse Rat
形态
宿主 Rabbit
标记物
包装规格
纯度 %
亚型 IgG
标识物
浓度 %
免疫原
是否进口
Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.
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