Anti-RICTOR Polyclonal Antibody
- 价格: ¥1600/支
- 发布日期: 2020-08-10
- 更新日期: 2023-09-28
产品详请
抗体名 |
RICTOR
|
是否单克隆 |
否
|
用途范围 |
Human Mouse Rat
|
宿主 |
Rabbit
|
纯度 |
%
|
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K009413P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
WB IHC IF ELISA
|
产品用途 |
WB IHC IF ELISA
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human Mouse Rat
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.