Anti-CPSF4 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108171P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-05-17
产品详请
抗体名 CPSF4
是否单克隆
用途范围 Human Mouse Rat
宿主 Rabbit
纯度 %
产地 北京
品牌 Solarbio
货号 K108171P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 IHC
产品用途 IHC
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
亚型 IgG
浓度 %
是否进口
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
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