产品目录
Anti-TERF2IP Polyclonal Antibody
物品单位 价格 品牌
1600 Solarbio
  • 产地:北京
  • 货号:K108266P
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
CAS编号
抗体名 TERF2IP
是否单克隆
靶点
用途范围 Human
形态
宿主
标记物
纯度 %
免疫原
产地 北京
品牌 Solarbio
货号 K108266P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB
抗原来源
保质期
规格
产品用途 WB
克隆性 Polyclonal Antibody
适应物种 Human
亚型 IgG
标识物
浓度 %
是否进口
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex; it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead; it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR); which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres; also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors; and regulates gene expression. When cytoplasmic; associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65; leading to activate expression of NF-kappa-B target genes.
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