Anti-ITPK1 Polyclonal Antibody
- 价格: ¥1600/支
- 发布日期: 2020-08-10
- 更新日期: 2023-09-21
产品详请
抗体名 |
ITPK1
|
是否单克隆 |
否
|
用途范围 |
Human Mouse
|
纯度 |
%
|
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K108275P
|
保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
应用范围 |
WB
|
产品用途 |
WB
|
克隆性 |
Polyclonal Antibody
|
适应物种 |
Human Mouse
|
亚型 |
IgG
|
浓度 |
%
|
是否进口 |
否
|
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3;4;5;6)P4 or Ins(1;3;4)P3. Phosphorylates Ins(3;4;5;6)P4 at position 1 to form Ins(1;3;4;5;6)P5. This reaction is thought to have regulatory importance; since Ins(3;4;5;6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl-?channels; while Ins(1;3;4;5;6)P5 is not. Also phosphorylates Ins(1;3;4)P3 on O-5 and O-6 to form Ins(1;3;4;6)P4; an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1;3;4;5)P4 and Ins(1;3;4;6)P4 to Ins(1;3;4)P3; and Ins(1;3;4;5;6)P5 to Ins(3;4;5;6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1;3;4;5)P4 and Ins(1;3;4;6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.