Anti-MAPK9 Polyclonal Antibody
- 发布日期: 2020-08-10
- 更新日期: 2024-11-13
产品详请
产地 |
北京
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品牌 |
Solarbio
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货号 |
K108292P
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保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
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用途 |
WB IHC
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应用范围 |
WB IHC
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抗原来源 |
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CAS编号 |
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保质期 |
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抗体名 |
MAPK9
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是否单克隆 |
否
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克隆性 |
Polyclonal Antibody
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靶点 |
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适应物种 |
Human Mouse Rat
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形态 |
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宿主 |
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标记物 |
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包装规格 |
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纯度 |
%
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亚型 |
IgG
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标识物 |
|
浓度 |
%
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免疫原 |
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是否进口 |
否
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Serine/threonine-protein kinase involved in various processes such as cell proliferation; differentiation; migration; transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade; two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn; MAPK9/JNK2 phosphorylates a number of transcription factors; primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses; inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells; MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation; is activated by CARMA1; BCL10; MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated; promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1; which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation.