北京索莱宝科技有限公司
产品展厅
Anti-MUL1 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108338P
  • 发布日期: 2020-08-10
  • 更新日期: 2025-04-28
产品详请
产地 北京
品牌 Solarbio
货号 K108338P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 IHC
应用范围 IHC
抗原来源
CAS编号
保质期
抗体名 MUL1
是否单克隆
克隆性 Polyclonal Antibody
靶点
适应物种 Human Mouse Rat
形态
宿主
标记物
包装规格
纯度 %
亚型 IgG
标识物
浓度 %
免疫原
是否进口
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization . Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
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