北京索莱宝科技有限公司
产品展厅
Anti-COPS2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108385P
  • 发布日期: 2020-08-10
  • 更新日期: 2024-11-06
产品详请
产地 北京
品牌 Solarbio
货号 K108385P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 WB
应用范围 WB
抗原来源
CAS编号
保质期
抗体名 COPS2
是否单克隆
克隆性 Polyclonal Antibody
靶点
适应物种 Human Mouse Rat Monkey
形态
宿主
标记物
包装规格
纯度 %
亚型 IgG
标识物
浓度 %
免疫原
是否进口
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
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