北京索莱宝科技有限公司
产品展厅
Anti-MORF4L1 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108250P
  • 发布日期: 2020-08-10
  • 更新日期: 2024-11-13
产品详请
产地 北京
品牌 Solarbio
货号 K108250P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 WB IHC
应用范围 WB IHC
抗原来源
CAS编号
保质期
抗体名 MORF4L1
是否单克隆
克隆性 Polyclonal Antibody
靶点
适应物种 Human Mouse Rat
形态
宿主
标记物
包装规格
纯度 %
亚型 IgG
标识物
浓度 %
免疫原
是否进口
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest and replicative senescence; apoptosis; and DNA repair. The NuA4 complex ATPase and helicase activities seem to be; at least in part; contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2; BRCA2 and RAD51; but not BRCA1; to DNA-damage foci.
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