产品目录
Anti-MORF4L1 Polyclonal Antibody
物品单位 价格 品牌
1600 Solarbio
  • 产地:北京
  • 货号:K108250P
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
CAS编号
抗体名 MORF4L1
是否单克隆
靶点
用途范围 Human Mouse Rat
形态
宿主
标记物
纯度 %
免疫原
产地 北京
品牌 Solarbio
货号 K108250P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB IHC
抗原来源
保质期
规格
产品用途 WB IHC
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
亚型 IgG
标识物
浓度 %
是否进口
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest and replicative senescence; apoptosis; and DNA repair. The NuA4 complex ATPase and helicase activities seem to be; at least in part; contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2; BRCA2 and RAD51; but not BRCA1; to DNA-damage foci.
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