Anti-S1PR1 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108442P
  • 价格: ¥1600/支
  • 发布日期: 2020-08-10
  • 更新日期: 2024-02-23
产品详请
抗体名 S1PR1
是否单克隆
用途范围 Human Mouse Rat
纯度 %
产地 北京
品牌 Solarbio
货号 K108442P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB
产品用途 WB
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
亚型 IgG
浓度 %
是否进口
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
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