Anti-RRP8 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108460P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-05-17
产品详请
抗体名 RRP8
是否单克隆
用途范围 Human Mouse Rat
纯度 %
产地 北京
品牌 Solarbio
货号 K108460P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB IHC
产品用途 WB IHC
克隆性 Polyclonal Antibody
适应物种 Human Mouse Rat
亚型 IgG
浓度 %
是否进口
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
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