Anti-RRP8 Polyclonal Antibody
- 发布日期: 2020-08-10
- 更新日期: 2024-11-06
产品详请
产地 |
北京
|
品牌 |
Solarbio
|
货号 |
K108460P
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保存条件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
用途 |
WB IHC
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应用范围 |
WB IHC
|
抗原来源 |
|
CAS编号 |
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保质期 |
|
抗体名 |
RRP8
|
是否单克隆 |
否
|
克隆性 |
Polyclonal Antibody
|
靶点 |
|
适应物种 |
Human Mouse Rat
|
形态 |
|
宿主 |
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标记物 |
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包装规格 |
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纯度 |
%
|
亚型 |
IgG
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标识物 |
|
浓度 |
%
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免疫原 |
|
是否进口 |
否
|
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.