Anti-ACKR2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108561P
  • 价格: ¥1600/支
  • 发布日期: 2020-08-10
  • 更新日期: 2024-02-23
产品详请
抗体名 ACKR2
是否单克隆
用途范围 Human
纯度 %
产地 北京
品牌 Solarbio
货号 K108561P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 IHC
产品用途 IHC
克隆性 Polyclonal Antibody
适应物种 Human
亚型 IgG
浓度 %
是否进口
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
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