Anti-PPP4R2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108577P
  • 价格: ¥询价
  • 发布日期: 2020-08-10
  • 更新日期: 2024-04-24
产品详请
抗体名 PPP4R2
是否单克隆
用途范围 Human
纯度 %
产地 北京
品牌 Solarbio
货号 K108577P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
应用范围 WB
产品用途 WB
克隆性 Polyclonal Antibody
适应物种 Human
亚型 IgG
浓度 %
是否进口
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
联系方式
手机:17801761073微信同号
Q Q:
微信扫一扫