北京索莱宝科技有限公司
产品展厅
Anti-PPP4R2 Polyclonal Antibody
  • 品牌:Solarbio
  • 产地:北京
  • 货号:K108577P
  • 发布日期: 2020-08-10
  • 更新日期: 2024-11-06
产品详请
产地 北京
品牌 Solarbio
货号 K108577P
保存条件 Store at -20°C. Avoid freeze / thaw cycles.
用途 WB
应用范围 WB
抗原来源
CAS编号
保质期
抗体名 PPP4R2
是否单克隆
克隆性 Polyclonal Antibody
靶点
适应物种 Human
形态
宿主
标记物
包装规格
纯度 %
亚型 IgG
标识物
浓度 %
免疫原
是否进口
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
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