产品目录
大鼠晚期糖基化终末产物受体 Elisa试剂盒
物品单位 价格 品牌
2600 Solarbio
  • 产地:北京
  • 货号:SEKR-0077
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
产地 北京
保存条件 -20
品牌 Solarbio
货号 SEKR-0077
检测方法 双抗体夹心法
CAS编号
保质期
规格
适应物种 Rat
检测限 31.2 - 2,000 pg/mL
数量 999
用途范围 Rat
标记物
纯度 %
样本 血清/血浆/细胞培养上清
应用 Elisa试剂盒
是否进口
RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.
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