人S100A8/S100A9异二聚体 Elisa试剂盒
- 发布日期: 2020-08-10
- 更新日期: 2024-12-06
产品详请
产地 |
北京
|
保存条件 |
-20
|
品牌 |
Solarbio
|
货号 |
SEKH-0423
|
用途 |
Human
|
检测方法 |
双抗体夹心法
|
CAS编号 |
|
保质期 |
|
适应物种 |
Human
|
检测限 |
93.8 - 6,000 pg/mL
|
数量 |
999
|
包装规格 |
|
标记物 |
|
纯度 |
%
|
样本 |
血清/血浆/细胞培养上清
|
应用 |
Elisa试剂盒
|
是否进口 |
否
|
S100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca2+-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively.