产品目录
人S100A8/S100A9异二聚体 Elisa试剂盒
物品单位 价格 品牌
3200 Solarbio
  • 产地:北京
  • 货号:SEKH-0423
  • 发布日期: 2020-08-10
  • 更新日期: 2020-08-10
产品详细说明
产地 北京
保存条件 -20
品牌 Solarbio
货号 SEKH-0423
检测方法 双抗体夹心法
CAS编号
保质期
规格
适应物种 Human
检测限 93.8 - 6,000 pg/mL
数量 999
用途范围 Human
标记物
纯度 %
样本 血清/血浆/细胞培养上清
应用 Elisa试剂盒
是否进口
S100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca2+-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively.
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