小鼠核苷酸结合寡聚化结构域样受体蛋白 3 Elisa试剂盒
  • 品牌:Solarbio
  • 产地:北京
  • 货号:SEKM-0179
  • 价格: ¥2600/盒
  • 发布日期: 2020-08-10
  • 更新日期: 2024-02-23
产品详请
产地 北京
保存条件 -20
品牌 Solarbio
货号 SEKM-0179
检测方法 双抗体夹心法
适应物种 Mouse
检测限 15.6-1000 pg/ml
数量 999
用途范围 Mouse
纯度 %
样本 血清/血浆/细胞培养上清
应用 Elisa试剂盒
是否进口
NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% and 93% aa identity with human and rat NLRP3, respectively. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 and 7, or LRR4-9.
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