人基质金属蛋白酶抑制剂3 Elisa试剂盒
- 发布日期: 2020-08-10
- 更新日期: 2024-11-13
产品详请
产地 |
北京
|
保存条件 |
-20
|
品牌 |
Solarbio
|
货号 |
SEKH-0512
|
用途 |
Human
|
检测方法 |
双抗体夹心法
|
CAS编号 |
|
保质期 |
|
适应物种 |
Human
|
检测限 |
62.5 - 4,000 pg/mL
|
数量 |
999
|
包装规格 |
|
标记物 |
|
纯度 |
%
|
样本 |
血清/血浆/细胞培养上清
|
应用 |
Elisa试剂盒
|
是否进口 |
否
|
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14