人诱导型一氧化氮合酶 Elisa试剂盒
- 发布日期: 2020-08-10
- 更新日期: 2025-05-09
产品详请
产地 |
北京
|
保存条件 |
-20
|
品牌 |
Solarbio
|
货号 |
SEKH-0501
|
用途 |
Human
|
检测方法 |
双抗体夹心法
|
CAS编号 |
|
保质期 |
|
适应物种 |
Human
|
检测限 |
62.5-4000 pg/mL
|
数量 |
999
|
包装规格 |
|
标记物 |
|
纯度 |
%
|
样本 |
血清/血浆/细胞培养上清
|
应用 |
Elisa试剂盒
|
是否进口 |
否
|
Inducible nitric oxide synthase (iNOS) is a widely expressed, approximately 130 kDa enzyme that catalyzes the conversion of L-arginine to nitric oxide (NO) plus citrulline. NO is a bioactive mediator that plays an important role in hemodynamics by inducing vascular smooth muscle relaxation. iNOS is constitutively expressed in the kidney. In other tissues, it is inducibly expressed during inflammation, oxidative stress, and hyperglycemia. iNOS activity is elevated in a variety of disease states including atherosclerosis, heart failure, sepsis, solid tumors, and type 2 diabetes. Increased production of NO mediates acute kidney injury, TNF-alpha induced muscle wasting, and the increased radiosensitivity of hypoxic tumor cells. Within amino acids 781-798, human iNOS shares 89% and 72% aa sequence identity with mouse and rat iNOS, respectively.